Analysis of HPV-Positive and HPV-Negative Head and Neck Squamous Cell Carcinomas and Paired Normal Mucosae Reveals Cyclin D1 Deregulation and Compensatory Effect of Cyclin D2

Analysis of HPV-Positive and HPV-Negative Head and Neck Squamous Cell Carcinomas and Paired Normal Mucosae Reveals Cyclin D1 Deregulation and Compensatory Effect of Cyclin D2

Aberrant regulation of the cell cycle is a typical feature of all forms of cancer. In head and neck squamous cell carcinoma (HNSCC), it is often associated with the overexpression of cyclin D1 (<i>CCND1</i>). However, it remains unclear how <i>CCND1</i> expression changes bet...

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Bibliographic Details
Main Authors: Jiří Novotný, Veronika Bandúrová, Hynek Strnad, Martin Chovanec, Miluše Hradilová, Jana Šáchová, Martin Šteffl, Josipa Grušanović, Roman Kodet, Václav Pačes, Lukáš Lacina, Karel Smetana Jr., Jan Plzák, Michal Kolář, Tomáš Vomastek
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Cancers
Subjects:
human papillomavirus
head and neck squamous cell carcinoma
cell cycle
d-type cyclins
<i>ccnd1</i>
<i>ccnd2</i>
<i>ccnd3</i>
patient survival
paired tumor-normal samples
11q13 amplification
Online Access:https://www.mdpi.com/2072-6694/12/4/792

Internet

https://www.mdpi.com/2072-6694/12/4/792

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