Prolonged treatment with pramipexole promotes physical interaction of striatal dopamine D3 autoreceptors with dopamine transporters to reduce dopamine uptake

Prolonged treatment with pramipexole promotes physical interaction of striatal dopamine D3 autoreceptors with dopamine transporters to reduce dopamine uptake

The dopamine (DA) transporter (DAT), a membrane glycoprotein expressed in dopaminergic neurons, clears DA from extracellular space and is regulated by diverse presynaptic proteins like protein kinases, α-synuclein, D2 and D3 autoreceptors. DAT dysfunction is implicated in Parkinson's disease an...

Full description

Bibliographic Details
Main Authors: Javier Castro-Hernández, Domingo Afonso-Oramas, Ignacio Cruz-Muros, Josmar Salas-Hernández, Pedro Barroso-Chinea, Rosario Moratalla, Mark J. Millan, Tomás González-Hernández
Format: Article
Language:English
Published: Elsevier 2015-02-01
Series:Neurobiology of Disease
Subjects:
Dopamine transporter
D3R
D2R
Dopamine autoreceptor
Multi-protein complex
Neuroprotection
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996114003787

Internet

http://www.sciencedirect.com/science/article/pii/S0969996114003787

Similar Items