Paradoxical Roles of Tumour Necrosis Factor-Alpha in Prostate Cancer Biology
Tumour necrosis factor (TNF) is a pleiotropic cytokine with dual roles in cancer biology including prostate cancer (PCa). On the one hand, there is evidence that it stimulates tumour angiogenesis, is involved in the initiation of PCa from an androgen-dependent to a castrate resistant state, plays a...
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Online Access: | http://dx.doi.org/10.1155/2012/128965 |
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doaj-86c165a6b1844a7a89c31559aa09770a2020-11-24T22:37:41ZengHindawi LimitedProstate Cancer2090-31112090-312X2012-01-01201210.1155/2012/128965128965Paradoxical Roles of Tumour Necrosis Factor-Alpha in Prostate Cancer BiologyBrian W. C. Tse0Kieran F. Scott1Pamela J. Russell2Australian Prostate Cancer Research Centre-Queensland, Queensland University of Technology, Brisbane, QLD 4102, AustraliaDepartment of Medicine, St. George Hospital Clinical School, The University of New South Wales, Sydney, NSW 2217, AustraliaAustralian Prostate Cancer Research Centre-Queensland, Queensland University of Technology, Brisbane, QLD 4102, AustraliaTumour necrosis factor (TNF) is a pleiotropic cytokine with dual roles in cancer biology including prostate cancer (PCa). On the one hand, there is evidence that it stimulates tumour angiogenesis, is involved in the initiation of PCa from an androgen-dependent to a castrate resistant state, plays a role in epithelial to mesenchymal plasticity, and may contribute to the aberrant regulation of eicosanoid pathways. On the other hand, TNF has also been reported to inhibit neovascularisation, induce apoptosis of PCa cells, and stimulate antitumour immunity. Much of the confusion surrounding its seemingly paradoxical roles in cancer biology stems from the dependence of its effects on the biological model within which TNF is investigated. This paper will address some of these issues and also discuss the therapeutic implications.http://dx.doi.org/10.1155/2012/128965 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Brian W. C. Tse Kieran F. Scott Pamela J. Russell |
spellingShingle |
Brian W. C. Tse Kieran F. Scott Pamela J. Russell Paradoxical Roles of Tumour Necrosis Factor-Alpha in Prostate Cancer Biology Prostate Cancer |
author_facet |
Brian W. C. Tse Kieran F. Scott Pamela J. Russell |
author_sort |
Brian W. C. Tse |
title |
Paradoxical Roles of Tumour Necrosis Factor-Alpha in Prostate Cancer Biology |
title_short |
Paradoxical Roles of Tumour Necrosis Factor-Alpha in Prostate Cancer Biology |
title_full |
Paradoxical Roles of Tumour Necrosis Factor-Alpha in Prostate Cancer Biology |
title_fullStr |
Paradoxical Roles of Tumour Necrosis Factor-Alpha in Prostate Cancer Biology |
title_full_unstemmed |
Paradoxical Roles of Tumour Necrosis Factor-Alpha in Prostate Cancer Biology |
title_sort |
paradoxical roles of tumour necrosis factor-alpha in prostate cancer biology |
publisher |
Hindawi Limited |
series |
Prostate Cancer |
issn |
2090-3111 2090-312X |
publishDate |
2012-01-01 |
description |
Tumour necrosis factor (TNF) is a pleiotropic cytokine with dual roles in cancer biology including prostate cancer (PCa). On the one hand, there is evidence that it stimulates tumour angiogenesis, is involved in the initiation of PCa from an androgen-dependent to a castrate resistant state, plays a role in epithelial to mesenchymal plasticity, and may contribute to the aberrant regulation of eicosanoid pathways. On the other hand, TNF has also been reported to inhibit neovascularisation, induce apoptosis of PCa cells, and stimulate antitumour immunity. Much of the confusion surrounding its seemingly paradoxical roles in cancer biology stems from the dependence of its effects on the biological model within which TNF is investigated. This paper will address some of these issues and also discuss the therapeutic implications. |
url |
http://dx.doi.org/10.1155/2012/128965 |
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