A Powerful Procedure for Pathway-Based Meta-analysis Using Summary Statistics Identifies 43 Pathways Associated with Type II Diabetes in European Populations.

Meta-analysis of multiple genome-wide association studies (GWAS) has become an effective approach for detecting single nucleotide polymorphism (SNP) associations with complex traits. However, it is difficult to integrate the readily accessible SNP-level summary statistics from a meta-analysis into m...

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Bibliographic Details
Main Authors: Han Zhang, William Wheeler, Paula L Hyland, Yifan Yang, Jianxin Shi, Nilanjan Chatterjee, Kai Yu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-06-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC4928884?pdf=render