Characterization and identification of subpopulations of mononuclear preosteoclasts induced by TNF-α in combination with TGF-β in rats.

Osteoclasts are unique multinucleated cells formed by fusion of preosteoclasts derived from cells of the monocyte/macrophage lineage, which are induced by RANKL. However, characteristics and subpopulations of osteoclast precursor cells are poorly understood. We show here that a combination of TNF-α,...

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Bibliographic Details
Main Authors: Rei Matsubara, Toshio Kukita, Yuka Ichigi, Ippei Takigawa, Peng-Fei Qu, Noboru Funakubo, Hiroshi Miyamoto, Kazuaki Nonaka, Akiko Kukita
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3480460?pdf=render