Evaluation in mice of a conjugate vaccine for cholera made from Vibrio cholerae O1 (Ogawa) O-specific polysaccharide.

Evaluation in mice of a conjugate vaccine for cholera made from Vibrio cholerae O1 (Ogawa) O-specific polysaccharide.

BACKGROUND:Protective immunity against cholera is serogroup specific. Serogroup specificity in Vibrio cholerae is determined by the O-specific polysaccharide (OSP) of lipopolysaccharide (LPS). Generally, polysaccharides are poorly immunogenic, especially in young children. METHODOLOGY:Here we report...

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Bibliographic Details
Main Authors: Mohammad Murshid Alam, Megan Kelly Bufano, Peng Xu, Anuj Kalsy, Y Yu, Y Wu Freeman, Tania Sultana, Md Rasheduzzaman Rashu, Ishaan Desai, Grace Eckhoff, Daniel T Leung, Richelle C Charles, Regina C LaRocque, Jason B Harris, John D Clements, Stephen B Calderwood, Firdausi Qadri, W F Vann, Pavol Kováč, Edward T Ryan
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-02-01
Series:PLoS Neglected Tropical Diseases
Online Access:http://europepmc.org/articles/PMC3916310?pdf=render

Internet

http://europepmc.org/articles/PMC3916310?pdf=render

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