SIRT5 deficiency suppresses mitochondrial ATP production and promotes AMPK activation in response to energy stress.

SIRT5 deficiency suppresses mitochondrial ATP production and promotes AMPK activation in response to energy stress.

Sirtuin 5 (SIRT5) is a member of the NAD+-dependent sirtuin family of protein deacylase that catalyzes removal of post-translational modifications, such as succinylation, malonylation, and glutarylation on lysine residues. In light of the SIRT5's roles in regulating mitochondrion function, we s...

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Bibliographic Details
Main Authors: Mengli Zhang, Jian Wu, Renqiang Sun, Xiaoting Tao, Xiaoxia Wang, Qi Kang, Hui Wang, Lei Zhang, Peng Liu, Jinye Zhang, Yukun Xia, Yuzheng Zhao, Yi Yang, Yue Xiong, Kun-Liang Guan, Yunzeng Zou, Dan Ye
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0211796

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https://doi.org/10.1371/journal.pone.0211796

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