Histological phenotypic subtypes predict recurrence risk and response to adjuvant chemotherapy in patients with stage III colorectal cancer

Histological phenotypic subtypes predict recurrence risk and response to adjuvant chemotherapy in patients with stage III colorectal cancer

Abstract Histological ‘phenotypic subtypes’ that classify patients into four groups (immune, canonical, latent and stromal) have previously been demonstrated to stratify survival in a stage I–III colorectal cancer (CRC) pilot cohort. However, clinical utility has not yet been validated. Therefore, t...

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Bibliographic Details
Main Authors: Antonia K Roseweir, James H Park, Sanne ten Hoorn, Arfon GMT Powell, Susan Aherne, Campbell SD Roxburgh, Donald C McMillan, Paul G Horgan, Elizabeth Ryan, Kieran Sheahan, Louis Vermeulen, James Paul, Andrea Harkin, Janet Graham, Owen Sansom, David N Church, Ian Tomlinson, Mark Saunders, Tim J Iveson, Joanne Edwards
Format: Article
Language:English
Published: Wiley 2020-10-01
Series:The Journal of Pathology: Clinical Research
Subjects:
colorectal cancer
subtyping
histopathology
adjuvant treatment
recurrence
precision medicine
Online Access:https://doi.org/10.1002/cjp2.171

Internet

https://doi.org/10.1002/cjp2.171

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