Sequential dosing in chemosensitization: targeting the PI3K/Akt/mTOR pathway in neuroblastoma.

Sequential dosing in chemosensitization: targeting the PI3K/Akt/mTOR pathway in neuroblastoma.

Breaking resistance to chemotherapy is a major goal of combination therapy in many tumors, including advanced neuroblastoma. We recently demonstrated that increased activity of the PI3K/Akt network is associated with poor prognosis, thus providing an ideal target for chemosensitization. Here we show...

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Bibliographic Details
Main Authors: Mike-Andrew Westhoff, Najmeh Faham, Daniela Marx, Lisa Nonnenmacher, Claudia Jennewein, Stefanie Enzenmüller, Patrick Gonzalez, Simone Fulda, Klaus-Michael Debatin
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3877010?pdf=render

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http://europepmc.org/articles/PMC3877010?pdf=render

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