Mycophenolic Acid for Topical Immunosuppression in Vascularized Composite Allotransplantation: Optimizing Formulation and Preliminary Evaluation of Bioavailability and Pharmacokinetics

Mycophenolic Acid for Topical Immunosuppression in Vascularized Composite Allotransplantation: Optimizing Formulation and Preliminary Evaluation of Bioavailability and Pharmacokinetics

Mycophenolic acid (MPA), is the active form of the ester prodrug mycophenolate mofetil (MMF). MMF is an FDA approved immunosuppressive drug that has been successfully used in systemic therapy in combination with other agents for the prevention of acute rejection (AR) following solid organ transplant...

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Bibliographic Details
Main Authors: Firuz G. Feturi, Matthias Weinstock, Wenchen Zhao, Wei Zhang, Jonas T. Schnider, Vasil E. Erbas, Sinan Oksuz, Jan A. Plock, Lisa Rohan, Alexander M. Spiess, Lydia M. Ferreira, Mario G. Solari, Raman Venkataramanan, Vijay S. Gorantla
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-05-01
Series:Frontiers in Surgery
Subjects:
mycophenolic acid
topical
formulation
permeability
immunosuppression
VCA
Online Access:http://journal.frontiersin.org/article/10.3389/fsurg.2018.00020/full

Internet

http://journal.frontiersin.org/article/10.3389/fsurg.2018.00020/full

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