ER-Stress-Induced Differentiation Sensitizes Colon Cancer Stem Cells to Chemotherapy

ER-Stress-Induced Differentiation Sensitizes Colon Cancer Stem Cells to Chemotherapy

Colon cancer stem cells (colon-CSCs) are more resistant to conventional chemotherapy than differentiated cancer cells. This subset of therapy refractory cells is therefore believed to play an important role in post-therapeutic tumor relapse. In order to improve the rate of sustained response to conv...

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Bibliographic Details
Main Authors: Mattheus C.B. Wielenga, Selcuk Colak, Jarom Heijmans, Jooske F. van Lidth de Jeude, Hans M. Rodermond, James C. Paton, Adrienne W. Paton, Louis Vermeulen, Jan Paul Medema, Gijs R. van den Brink
Format: Article
Language:English
Published: Elsevier 2015-10-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S221112471501027X

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http://www.sciencedirect.com/science/article/pii/S221112471501027X

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