Hepatic lipase overexpression lowers remnant and LDL levels by a noncatalytic mechanism in LDL receptor-deficient mice

Hepatic lipase overexpression lowers remnant and LDL levels by a noncatalytic mechanism in LDL receptor-deficient mice

To address the role of the noncatalytic ligand function of hepatic lipase (HL) in low density lipoprotein (LDL) receptor-mediated lipoprotein metabolism, we characterized transgenic mice lacking the LDL receptor (LDLR) that express either catalytically active (Ldlr−/−HL) or inactive (Ldlr−/−HLS145G)...

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Bibliographic Details
Main Authors: Helén L. Dichek, Sarah M. Johnson, Hassibullah Akeefe, Giai T. Lo, Ezra Sage, Christine E. Yap, Robert W. Mahley
Format: Article
Language:English
Published: Elsevier 2001-02-01
Series:Journal of Lipid Research
Subjects:
noncatalytic function
ligand function
apoB-100
FPLC
Western diet
phospholipase A1 activity
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520316801

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http://www.sciencedirect.com/science/article/pii/S0022227520316801

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