Essential roles of mitochondrial biogenesis regulator Nrf1 in retinal development and homeostasis

Essential roles of mitochondrial biogenesis regulator Nrf1 in retinal development and homeostasis

Abstract Background Mitochondrial dysfunction has been implicated in the pathologies of a number of retinal degenerative diseases in both the outer and inner retina. In the outer retina, photoreceptors are particularly vulnerable to mutations affecting mitochondrial function due to their high energy...

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Bibliographic Details
Main Authors: Takae Kiyama, Ching-Kang Chen, Steven W Wang, Ping Pan, Zhenlin Ju, Jing Wang, Shinako Takada, William H Klein, Chai-An Mao
Format: Article
Language:English
Published: BMC 2018-10-01
Series:Molecular Neurodegeneration
Subjects:
Mitochondrial biogenesis
Nrf1
Retinal progenitor cell
Retinal ganglion cell
Optic atrophy
Photoreceptor degeneration
Online Access:http://link.springer.com/article/10.1186/s13024-018-0287-z

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http://link.springer.com/article/10.1186/s13024-018-0287-z

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