Innate Signaling in the CNS Prevents Demyelination in a Focal EAE Model

Innate Signaling in the CNS Prevents Demyelination in a Focal EAE Model

The pathological hallmark of multiple sclerosis (MS) is the formation of multifocal demyelinating lesions in the central nervous system (CNS). Stimulation of innate receptors has been shown to suppress experimental autoimmune encephalomyelitis (EAE), an MS-like disease in mice. Specifically, targeti...

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Bibliographic Details
Main Authors: Magdalena Dubik, Joanna Marczynska, Marlene T. Mørch, Gill Webster, Kirstine Nolling Jensen, Agnieszka Wlodarczyk, Reza Khorooshi, Trevor Owens
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Neuroscience
Subjects:
innate signaling
demyelination
focal EAE
myeloid cells
NK cells
T-cells
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2021.682451/full

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https://www.frontiersin.org/articles/10.3389/fnins.2021.682451/full

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