TDP-43-mediated neuron loss in vivo requires RNA-binding activity.

TDP-43-mediated neuron loss in vivo requires RNA-binding activity.

Alteration and/or mutations of the ribonucleoprotein TDP-43 have been firmly linked to human neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). The relative impacts of TDP-43 alteration, mutation, or inherent protein function on ne...

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Bibliographic Details
Main Authors: Aaron Voigt, David Herholz, Fabienne C Fiesel, Kavita Kaur, Daniel Müller, Peter Karsten, Stephanie S Weber, Philipp J Kahle, Till Marquardt, Jörg B Schulz
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2923622?pdf=render

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http://europepmc.org/articles/PMC2923622?pdf=render

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