Evidence that a positive feedback loop drives centrosome maturation in fly embryos

Evidence that a positive feedback loop drives centrosome maturation in fly embryos

Centrosomes are formed when mother centrioles recruit pericentriolar material (PCM) around themselves. The PCM expands dramatically as cells prepare to enter mitosis (a process termed centrosome maturation), but it is unclear how this expansion is achieved. In flies, Spd-2 and Cnn are thought to for...

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Bibliographic Details
Main Authors: Ines Alvarez-Rodrigo, Thomas L Steinacker, Saroj Saurya, Paul T Conduit, Janina Baumbach, Zsofia A Novak, Mustafa G Aydogan, Alan Wainman, Jordan W Raff
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-09-01
Series:eLife
Subjects:
centrosome
pericentriolar material
polo kinase
Spd-2
feedback loop
centriole
Online Access:https://elifesciences.org/articles/50130

Internet

https://elifesciences.org/articles/50130

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