FAD binding, cobinamide binding and active site communication in the corrin reductase (CobR)

FAD binding, cobinamide binding and active site communication in the corrin reductase (CobR)

Adenosylcobalamin, the coenzyme form of vitamin B12, is one Nature's most complex coenzyme whose de novo biogenesis proceeds along either an anaerobic or aerobic metabolic pathway. The aerobic synthesis involves reduction of the centrally chelated cobalt metal ion of the corrin ring from Co(II...

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Bibliographic Details
Main Authors: Andrew D. Lawrence, Samantha L. Taylor, Alan Scott, Michelle L. Rowe, Christopher M. Johnson, Stephen E. J. Rigby, Michael A. Geeves, Richard W. Pickersgill, Mark J. Howard, Martin J. Warren
Format: Article
Language:English
Published: Portland Press, Biochemical Society 2014-07-01
Series:Bioscience Reports
Subjects:
enzyme kinetics
enzyme structure
NMR
vitamins and cofactors
X-ray crystallography
Online Access:http://www.bioscirep.org/bsr/034/e120/bsr034e120.htm

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