Controlled Release of 5-FU from Chi–DHA Nanoparticles Synthetized with Ionic Gelation Technique: Evaluation of Release Profile Kinetics and Cytotoxicity Effect

Controlled Release of 5-FU from Chi–DHA Nanoparticles Synthetized with Ionic Gelation Technique: Evaluation of Release Profile Kinetics and Cytotoxicity Effect

The ionic gelation technique allows us to obtain nanoparticles able to function as carriers for hydrophobic anticancer drugs, such as 5-fluoruracil (5-FU). In this study, reticulated chitosan– docosahexaenoic acid (Chi–DHAr) nanoparticles were synthesized by using a chemical reaction between amine g...

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Bibliographic Details
Main Authors: Mariarosa Ruffo, Ortensia Ilaria Parisi, Francesco Patitucci, Marco Dattilo, Rocco Malivindi, Fabio Amone, Catia Morelli, Alessandra Nigro, Diego Sisci, Francesco Puoci
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Journal of Functional Biomaterials
Subjects:
Chi-DHAr nanoparticles
drug delivery
5-FU
release profile
cytotoxicity studies
Online Access:https://www.mdpi.com/2079-4983/11/3/48

Internet

https://www.mdpi.com/2079-4983/11/3/48

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