Resveratrol mediates mechanical allodynia through modulating inflammatory response via the TREM2-autophagy axis in SNI rat model

Resveratrol mediates mechanical allodynia through modulating inflammatory response via the TREM2-autophagy axis in SNI rat model

Abstract Background Neuropathic pain (NeuP) is a chronic and challenging clinical problem, with little effective treatment. Resveratrol has shown neuroprotection by inhibiting inflammatory response in NeuP. Recently, the triggering receptor expressed on myeloid cells 2 (TREM2) expressed by microglia...

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Bibliographic Details
Main Authors: Yaping Wang, Yu Shi, Yongquan Huang, Wei Liu, Guiyuan Cai, Shimin Huang, Yanyan Zeng, Siqiang Ren, Hongrui Zhan, Wen Wu
Format: Article
Language:English
Published: BMC 2020-10-01
Series:Journal of Neuroinflammation
Subjects:
TREM2
Resveratrol
Microglia
Autophagy
Neuropathic pain
Online Access:http://link.springer.com/article/10.1186/s12974-020-01991-2

Internet

http://link.springer.com/article/10.1186/s12974-020-01991-2

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