SDF-1 Inhibition Targets the Bone Marrow Niche for Cancer Therapy

SDF-1 Inhibition Targets the Bone Marrow Niche for Cancer Therapy

Summary: Bone marrow (BM) metastasis remains one of the main causes of death associated with solid tumors as well as multiple myeloma (MM). Targeting the BM niche to prevent or modulate metastasis has not been successful to date. Here, we show that stromal cell-derived factor-1 (SDF-1/CXCL12) is hig...

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Bibliographic Details
Main Authors: Aldo M. Roccaro, Antonio Sacco, Werner G. Purschke, Michele Moschetta, Klaus Buchner, Christian Maasch, Dirk Zboralski, Stefan Zöllner, Stefan Vonhoff, Yuji Mishima, Patricia Maiso, Michaela R. Reagan, Silvia Lonardi, Marco Ungari, Fabio Facchetti, Dirk Eulberg, Anna Kruschinski, Axel Vater, Giuseppe Rossi, Sven Klussmann, Irene M. Ghobrial
Format: Article
Language:English
Published: Elsevier 2014-10-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124714007189

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http://www.sciencedirect.com/science/article/pii/S2211124714007189

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