TNF-α Increases Production of Reactive Oxygen Species through Cdk5 Activation in Nociceptive Neurons

TNF-α Increases Production of Reactive Oxygen Species through Cdk5 Activation in Nociceptive Neurons

The participation of reactive oxygen species (ROS) generated by NOX1 and NOX2/NADPH oxidase has been documented during inflammatory pain. However, the molecular mechanism involved in their activation is not fully understood. We reported earlier a key role of Cyclin-dependent kinase 5 (Cdk5) during i...

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Bibliographic Details
Main Authors: Rodrigo Sandoval, Pablo Lazcano, Franco Ferrari, Nicolás Pinto-Pardo, Christian González-Billault, Elías Utreras
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-02-01
Series:Frontiers in Physiology
Subjects:
Cdk5
NOX
TNF-α
pain signaling
ROS
Online Access:http://journal.frontiersin.org/article/10.3389/fphys.2018.00065/full

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http://journal.frontiersin.org/article/10.3389/fphys.2018.00065/full

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