Intradermal delivery of receptor‐binding domain of SARS‐CoV‐2 spike protein with dissolvable microneedles to induce humoral and cellular responses in mice

Intradermal delivery of receptor‐binding domain of SARS‐CoV‐2 spike protein with dissolvable microneedles to induce humoral and cellular responses in mice

Abstract The S1 subunit of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) spike protein contains an immunogenic receptor‐binding domain (RBD), which is a promising candidate for the development of a potential vaccine. This study demonstrated that intradermal delivery of an S‐RBD vaccin...

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Bibliographic Details
Main Authors: Chaiyaporn Kuwentrai, Jinming Yu, Li Rong, Bao‐Zhong Zhang, Ye‐Fan Hu, Hua‐Rui Gong, Ying Dou, Jian Deng, Jian‐Dong Huang, Chenjie Xu
Format: Article
Language:English
Published: Wiley 2021-01-01
Series:Bioengineering & Translational Medicine
Subjects:
COVID‐19
intradermal delivery
microneedle
receptor‐binding domain
SARS‐CoV‐2
spike protein
Online Access:https://doi.org/10.1002/btm2.10202

Internet

https://doi.org/10.1002/btm2.10202

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