Vitamin D3 Metabolites Demonstrate Prognostic Value in <i>EGFR</i>-Mutant Lung Adenocarcinoma and Can be Deployed to Oppose Acquired Therapeutic Resistance

Vitamin D3 Metabolites Demonstrate Prognostic Value in <i>EGFR</i>-Mutant Lung Adenocarcinoma and Can be Deployed to Oppose Acquired Therapeutic Resistance

EGFR tyrosine kinase inhibitors (EGFR TKIs) are the standard of care treatment for patients with <i>EGFR</i>-mutant lung adenocarcinoma (LUAD). Although initially effective, EGFR TKIs are not curative. Disease inevitably relapses due to acquired drug resistance. We hypothesized that vita...

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Bibliographic Details
Main Authors: Tatiana Shaurova, Grace K Dy, Sebastiano Battaglia, Alan Hutson, Letian Zhang, Yunkai Zhang, Christine M Lovly, Mukund Seshadri, David W Goodrich, Candace S Johnson, Pamela A Hershberger
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Cancers
Subjects:
lung cancer
egfr
tyrosine kinase inhibitor
vitamin d
epithelial–mesenchymal transition
Online Access:https://www.mdpi.com/2072-6694/12/3/675

Internet

https://www.mdpi.com/2072-6694/12/3/675

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