Association of a PAI-1 Gene Polymorphism and Early Life Infections with Asthma Risk, Exacerbations, and Reduced Lung Function.

Association of a PAI-1 Gene Polymorphism and Early Life Infections with Asthma Risk, Exacerbations, and Reduced Lung Function.

BACKGROUND:Plasminogen activator inhibitor-1 (PAI-1) is induced in airways by virus and may mediate asthmatic airway remodeling. We sought to evaluate if genetic variants and early life lower respiratory infections jointly affect asthma risk. METHODS:We included Latino children, adolescents, and you...

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Bibliographic Details
Main Authors: Seong H Cho, Jin-Young Min, Dong Young Kim, Sam S Oh, Dara R Torgerson, Maria Pino-Yanes, Donglei Hu, Saunak Sen, Scott Huntsman, Celeste Eng, Harold J Farber, William Rodriguez-Cintron, Jose R Rodriguez-Santana, Denise Serebrisky, Shannon M Thyne, Luisa N Borrell, L Keoki Williams, William DuPont, Max A Seibold, Esteban G Burchard, Pedro C Avila, Rajesh Kumar
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4996454?pdf=render

Internet

http://europepmc.org/articles/PMC4996454?pdf=render

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