An automated real-time microfluidic platform to probe single NK cell heterogeneity and cytotoxicity on-chip

Abstract Cytotoxicity is a vital effector mechanism used by immune cells to combat pathogens and cancer cells. While conventional cytotoxicity assays rely on averaged end-point measures, crucial insights on the dynamics and heterogeneity of effector and target cell interactions cannot be extracted,...

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Bibliographic Details
Main Authors: Nikita Subedi, Laura C. Van Eyndhoven, Ayla M. Hokke, Lars Houben, Mark C. Van Turnhout, Carlijn V. C. Bouten, Klaus Eyer, Jurjen Tel
Format: Article
Language:English
Published: Nature Publishing Group 2021-08-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-96609-9