JNK1 phosphorylates SIRT1 and promotes its enzymatic activity.

JNK1 phosphorylates SIRT1 and promotes its enzymatic activity.

SIRT1 is a NAD-dependent deacetylase that regulates a variety of pathways including the stress protection pathway. SIRT1 deacetylates a number of protein substrates, including histones, FOXOs, PGC-1alpha, and p53, leading to cellular protection. We identified a functional interaction between cJUN N-...

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Bibliographic Details
Main Authors: Nargis Nasrin, Virendar K Kaushik, Eric Fortier, Daniel Wall, Kevin J Pearson, Rafael de Cabo, Laura Bordone
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-12-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2793009?pdf=render

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http://europepmc.org/articles/PMC2793009?pdf=render

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