Conophylline inhibits high fat diet-induced non-alcoholic fatty liver disease in mice.

Conophylline inhibits high fat diet-induced non-alcoholic fatty liver disease in mice.

Conophylline (CnP), a vinca alkaloid extracted from the leaves of the tropical plant Tabernaemontana divaricate, attenuates hepatic fibrosis in mice. We have previously shown that CnP inhibits non-alcoholic steatohepatitis (NASH) using a methionine-choline-deficient (MCD) diet-fed mouse model. Howev...

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Bibliographic Details
Main Authors: Tomohiko Ohashi, Yukiomi Nakade, Mayu Ibusuki, Rena Kitano, Taeko Yamauchi, Satoshi Kimoto, Tadahisa Inoue, Yuji Kobayashi, Yoshio Sumida, Kiyoaki Ito, Haruhisa Nakao, Kazuo Umezawa, Masashi Yoneda
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0210068

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https://doi.org/10.1371/journal.pone.0210068

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