Physiologically Relevant Fluid-Induced Oscillatory Shear Stress Stimulation of Mesenchymal Stem Cells Enhances the Engineered Valve Matrix Phenotype

Physiologically Relevant Fluid-Induced Oscillatory Shear Stress Stimulation of Mesenchymal Stem Cells Enhances the Engineered Valve Matrix Phenotype

Support of somatic growth is a fundamental requirement of tissue-engineered valves. However, efforts thus far have been unable to maintain this support long term. A key event that will determine the valve's long-term success is the extent to which healthy host tissue remodeling can occur on the...

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Bibliographic Details
Main Authors: Brittany A. Gonzalez, Manuel Perez-Nevarez, Asad Mirza, Marcos Gonzalez Perez, Yih-Mei Lin, Chia-Pei Denise Hsu, Allen Caobi, Andrea Raymond, Mario E. Gomez Hernandez, Francisco Fernandez-Lima, Florence George, Sharan Ramaswamy
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
somatic growth
engineered valve
mechanical conditioning
physiologically relevant
mesenchymal stem cells
endothelial phenotype
Online Access:https://www.frontiersin.org/article/10.3389/fcvm.2020.00069/full

Internet

https://www.frontiersin.org/article/10.3389/fcvm.2020.00069/full

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