Designing gene panels for tumor mutational burden estimation: the need to shift from ‘correlation’ to ‘accuracy’

Designing gene panels for tumor mutational burden estimation: the need to shift from ‘correlation’ to ‘accuracy’

Abstract Tumor mutational burden (TMB) assessment is at the forefront in precision medicine. The TMB could represent a biomarker for immune checkpoint inhibitors (ICIs) responses. Whole exome sequencing (WES) is the gold standard to derive the TMB; while targeted next-generation sequencing panels mi...

Full description

Bibliographic Details
Main Authors: Hao-Xiang Wu, Zi-Xian Wang, Qi Zhao, Feng Wang, Rui-Hua Xu
Format: Article
Language:English
Published: BMJ Publishing Group 2019-08-01
Series:Journal for ImmunoTherapy of Cancer
Subjects:
Accuracy
Correlation
Panel
TCGA
Tumor mutational burden
Online Access:http://link.springer.com/article/10.1186/s40425-019-0681-2

Internet

http://link.springer.com/article/10.1186/s40425-019-0681-2

Similar Items