Mitochondrial DNA leakage induces odontoblast inflammation via the cGAS-STING pathway

Mitochondrial DNA leakage induces odontoblast inflammation via the cGAS-STING pathway

Abstract Background Mitochondrial DNA (mtDNA) is a vital driver of inflammation when it leaks from damaged mitochondria into the cytosol. mtDNA stress may contribute to cyclic GMP-AMP synthase (cGAS) stimulator of interferon genes (STING) pathway activation in infectious diseases. Odontoblasts are t...

Full description

Bibliographic Details
Main Authors: Lu Zhou, Yi-Fei Zhang, Fu-Hua Yang, Han-Qing Mao, Zhi Chen, Lu Zhang
Format: Article
Language:English
Published: BMC 2021-05-01
Series:Cell Communication and Signaling
Subjects:
Mitochondrial DNA
Mitochondrial damage
cGAS-STING pathway
Odontoblasts
Inflammation
Immune response
Online Access:https://doi.org/10.1186/s12964-021-00738-7

Internet

https://doi.org/10.1186/s12964-021-00738-7

Similar Items