The Structure of Blood Coagulation Factor XIII Is Adapted to Oxidation

The Structure of Blood Coagulation Factor XIII Is Adapted to Oxidation

The blood coagulation factor XIII (FXIII) plays a critical role in supporting coagulation and fibrinolysis due to both the covalent crosslinking of fibrin polymers, rendering them resistant to plasmin lysis, and the crosslinking of fibrin to proteins of the fibrinolytic system. The hypochlorite-medi...

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Bibliographic Details
Main Authors: Alexandra Vasilyeva, Lyubov Yurina, Alexander Shchegolikhin, Maria Indeykina, Anna Bugrova, Alexey Kononikhin, Eugene Nikolaev, Mark Rosenfeld
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:Biomolecules
Subjects:
blood coagulation factor XIII (FXIII)
hypochlorite-induced oxidation
oxidative modifications
reactive oxygen species (ROS)
HPLC-MS/MS
structural adaptation
Online Access:https://www.mdpi.com/2218-273X/10/6/914

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https://www.mdpi.com/2218-273X/10/6/914

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