Synthesis of New Lipophilic Phosphonate and Phosphonamidate Analogues of N-Acetylmuramyl-L-alanyl-D-isoglutamine Related to LK 423

Synthesis of New Lipophilic Phosphonate and Phosphonamidate Analogues of N-Acetylmuramyl-L-alanyl-D-isoglutamine Related to LK 423

A syntheses of three new muramyl dipeptide (MDP) analogues related to LK 423 as potential immunomodulators are presented. The dipeptide part of the lead compound was modified by introducing a phosphonamide isostere instead of the amide bond between Lalanine and D-glutamic acid (or D-isoglutamine), y...

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Bibliographic Details
Main Authors: Uroš Urleb, Stanislav Gobec
Format: Article
Language:English
Published: MDPI AG 2002-05-01
Series:Molecules
Subjects:
Muramyl dipeptide
analogues
phosphonamidates
phosphonates
immunomodulators
Online Access:http://www.mdpi.com/1420-3049/7/4/394/

Internet

http://www.mdpi.com/1420-3049/7/4/394/

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