Combined Targeting of Estrogen Receptor Alpha and Exportin 1 in Metastatic Breast Cancers

Combined Targeting of Estrogen Receptor Alpha and Exportin 1 in Metastatic Breast Cancers

The majority of breast cancer specific deaths in women with estrogen receptor positive (ER<sup>+</sup>) tumors occur due to metastases that are resistant to therapy. There is a critical need for novel therapeutic approaches to achieve tumor regression and/or maintain therapy responsivene...

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Bibliographic Details
Main Authors: Eylem Kulkoyluoglu Cotul, Qianying Zuo, Ashlie Santaliz-Casiano, Ozan Berk Imir, Ayca Nazli Mogol, Elif Tunc, Kevin Duong, Jenna Kathryn Lee, Rithva Ramesh, Elijah Odukoya, Mrinali P. Kesavadas, Monika Ziogaite, Brandi Patrice Smith, Chengjian Mao, David J. Shapiro, Ben Ho Park, Benita S. Katzenellenbogen, Drew Daly, Evelyn Aranda, John D. O’Neill, Christopher Walker, Yosef Landesman, Zeynep Madak-Erdogan
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:Cancers
Subjects:
breast cancer
<i>ESR1</i> mutant models
combination therapies
metabolic rewiring
glutamine
tamoxifen
Online Access:https://www.mdpi.com/2072-6694/12/9/2397

Internet

https://www.mdpi.com/2072-6694/12/9/2397

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