The Generation of Mouse and Human Huntington Disease iPS Cells Suitable for In vitro Studies on Huntingtin Function

The Generation of Mouse and Human Huntington Disease iPS Cells Suitable for In vitro Studies on Huntingtin Function

Huntington disease (HD) is an incurable neurodegenerative disorder caused by expansion of CAG repeats in huntingtin (HTT) gene, resulting in expanded polyglutamine tract in HTT protein. Although, HD has its common onset in adulthood, subtle symptoms in patients may occur decades before diagnosis, an...

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Bibliographic Details
Main Authors: Wojciech J. Szlachcic, Kalina Wiatr, Marta Trzeciak, Marek Figlerowicz, Maciej Figiel
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-08-01
Series:Frontiers in Molecular Neuroscience
Subjects:
Huntington disease
iPS cells
NS cells
YAC128
shRNA
huntingtin
Online Access:http://journal.frontiersin.org/article/10.3389/fnmol.2017.00253/full

Internet

http://journal.frontiersin.org/article/10.3389/fnmol.2017.00253/full

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