Integration of whole-exome and anchored PCR-based next generation sequencing significantly increases detection of actionable alterations in precision oncology

Integration of whole-exome and anchored PCR-based next generation sequencing significantly increases detection of actionable alterations in precision oncology

Background: Frequency of clinically relevant mutations in solid tumors by targeted and whole-exome sequencing is ∼30%. Transcriptome analysis complements detection of actionable gene fusions in advanced cancer patients. Goal of this study was to determine the added value of anchored multiplex PCR (A...

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Bibliographic Details
Main Authors: Shaham Beg, Rohan Bareja, Kentaro Ohara, Kenneth Wha Eng, David C. Wilkes, David J. Pisapia, Wael Al Zoughbi, Sarah Kudman, Wei Zhang, Rema Rao, Jyothi Manohar, Troy Kane, Michael Sigouros, Jenny Zhaoying Xiang, Francesca Khani, Brian D. Robinson, Bishoy M. Faltas, Cora N. Sternberg, Andrea Sboner, Himisha Beltran, Olivier Elemento, Juan Miguel Mosquera
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Translational Oncology
Subjects:
Anchored multiplex PCR-based next-generation sequencing
Whole-exome sequencing
RNA Sequencing
Novel fusion
Oncogenic
Online Access:http://www.sciencedirect.com/science/article/pii/S1936523320304368

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http://www.sciencedirect.com/science/article/pii/S1936523320304368

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