Role of Keap1-Nrf2 Signaling in Anhedonia Symptoms in a Rat Model of Chronic Neuropathic Pain: Improvement With Sulforaphane

Role of Keap1-Nrf2 Signaling in Anhedonia Symptoms in a Rat Model of Chronic Neuropathic Pain: Improvement With Sulforaphane

Patients with chronic neuropathic pain frequently suffer from symptoms of anhedonia (loss of pleasure), which is a core clinical manifestation of depression. Accumulating studies have shown the beneficial effects of the natural compound sulforaphane (SFN), an activator of nuclear factor (erythroid-d...

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Bibliographic Details
Main Authors: Shan Li, Chun Yang, Xi Fang, Gaofeng Zhan, Niannian Huang, Jie Gao, Hui Xu, Kenji Hashimoto, Ailin Luo
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Pharmacology
Subjects:
pain
anhedonia
sulforaphane
Keap1-Nrf2
medial prefrontal cortex
hippocampus
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.00887/full

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https://www.frontiersin.org/article/10.3389/fphar.2018.00887/full

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