Boosting the Synthesis of Pharmaceutically Active Abietane Diterpenes in S. sclarea Hairy Roots by Engineering the GGPPS and CPPS Genes

Boosting the Synthesis of Pharmaceutically Active Abietane Diterpenes in S. sclarea Hairy Roots by Engineering the GGPPS and CPPS Genes

Abietane diterpenoids (ADs), synthesized in the roots of different Salvia species, such as aethiopinone, 1-oxoaethiopinone, salvipisone, and ferruginol, have a variety of known biological activities. We have shown that aethiopinone has promising cytotoxic activity against several human tumor cell li...

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Bibliographic Details
Main Authors: Maria Carmela Vaccaro, Mariaevelina Alfieri, Nunziatina De Tommasi, Tessa Moses, Alain Goossens, Antonietta Leone
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Plant Science
Subjects:
metabolic engineering
plant bioactive diterpenes
gene co-expression
silencing
MEP-pathway
Online Access:https://www.frontiersin.org/article/10.3389/fpls.2020.00924/full

Internet

https://www.frontiersin.org/article/10.3389/fpls.2020.00924/full

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