New noncovalent inhibitors of penicillin-binding proteins from penicillin-resistant bacteria.

New noncovalent inhibitors of penicillin-binding proteins from penicillin-resistant bacteria.

BACKGROUND: Penicillin-binding proteins (PBPs) are well known and validated targets for antibacterial therapy. The most important clinically used inhibitors of PBPs β-lactams inhibit transpeptidase activity of PBPs by forming a covalent penicilloyl-enzyme complex that blocks the normal transpeptidat...

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Bibliographic Details
Main Authors: Samo Turk, Olivier Verlaine, Thomas Gerards, Matej Zivec, Jan Humljan, Izidor Sosič, Ana Amoroso, Astrid Zervosen, André Luxen, Bernard Joris, Stanislav Gobec
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3090393?pdf=render

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http://europepmc.org/articles/PMC3090393?pdf=render

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