Chiral Pyridine-3,5-bis- (L-phenylalaninyl-L-leucinyl) Schiff Base Peptides as Potential Anticancer Agents: Design, Synthesis, and Molecular Docking Studies Targeting Lactate Dehydrogenase-A

Chiral Pyridine-3,5-bis- (L-phenylalaninyl-L-leucinyl) Schiff Base Peptides as Potential Anticancer Agents: Design, Synthesis, and Molecular Docking Studies Targeting Lactate Dehydrogenase-A

A series of branched tetrapeptide Schiff bases <b>3</b>&#8722;<b>6</b> were designed and synthesized from corresponding tetrapeptide hydrazide <b>2</b> as a starting material.In vitroevaluation of the synthesized compounds <b>4</b>&#8722;<b&...

Full description

Bibliographic Details
Main Authors: Abd El-Galil E. Amr, Randa E. Abdel Mageid, Mohamed El-Naggar, Ahmed M. Naglah, Eman S. Nossier, Elsayed A. Elsayed
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:Molecules
Subjects:
amino acids
tetrapeptides
schiff bases
anticancer evaluation
p53 ubiquitination
ldha
molecular docking
Online Access:https://www.mdpi.com/1420-3049/25/5/1096

Internet

https://www.mdpi.com/1420-3049/25/5/1096

Similar Items