Honokiol Prevents Non-Alcoholic Steatohepatitis-Induced Liver Cancer via EGFR Degradation through the Glucocorticoid Receptor—MIG6 Axis

Honokiol Prevents Non-Alcoholic Steatohepatitis-Induced Liver Cancer via EGFR Degradation through the Glucocorticoid Receptor—MIG6 Axis

Non-alcoholic steatohepatitis (NASH) has become a serious public health problem associated with metabolic syndrome. The mechanisms by which NASH induces hepatocellular carcinoma (HCC) remain unknown. There are no approved drugs for treating NASH or preventing NASH-induced HCC. We used a genetic mous...

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Bibliographic Details
Main Authors: Keiichiro Okuda, Atsushi Umemura, Shiori Umemura, Seita Kataoka, Hiroyoshi Taketani, Yuya Seko, Taichiro Nishikawa, Kanji Yamaguchi, Michihisa Moriguchi, Yoshihiro Kanbara, Jack L. Arbiser, Toshihide Shima, Takeshi Okanoue, Michael Karin, Yoshito Itoh
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Cancers
Subjects:
liver cancer
glucocorticoid receptor
MIG-6/ERRFI1
epidermal growth factor receptor (EGFR)
honokiol
Online Access:https://www.mdpi.com/2072-6694/13/7/1515

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https://www.mdpi.com/2072-6694/13/7/1515

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