Pyrazinamide resistance and mutations in pncA among isolates of Mycobacterium tuberculosis from Khyber Pakhtunkhwa, Pakistan

Pyrazinamide resistance and mutations in pncA among isolates of Mycobacterium tuberculosis from Khyber Pakhtunkhwa, Pakistan

Abstract Background Pyrazinamide (PZA) is an important component of first-line drugs because of its distinctive capability to kill subpopulations of persistent Mycobacterium tuberculosis (MTB). The prodrug (PZA) is converted to its active form, pyrazinoic acid (POA) by MTB pncA-encoded pyrazinamidas...

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Bibliographic Details
Main Authors: Muhammad Tahir khan, Shaukat Iqbal Malik, Sajid Ali, Nayyer Masood, Tariq Nadeem, Anwar Sheed Khan, Muhammad Tanvir Afzal
Format: Article
Language:English
Published: BMC 2019-02-01
Series:BMC Infectious Diseases
Subjects:
Pyrazinamide
Resistance
Mutations
pncA
Online Access:http://link.springer.com/article/10.1186/s12879-019-3764-2

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http://link.springer.com/article/10.1186/s12879-019-3764-2

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