Programmed cell death protein-1 (PD-1) protects liver damage by suppressing IFN-γ expression in T cells in infants and neonatal mice

Programmed cell death protein-1 (PD-1) protects liver damage by suppressing IFN-γ expression in T cells in infants and neonatal mice

Abstract Background Biliary atresia (BA) is a severe cholangiopathy possibly resulting from virus-induced and immune-mediated injury of the biliary system. IFN-γ, secreted from CD4+ Th1 cells and CD8+ cytotoxic T cells, is a major mediator of liver pathology. Programmed death protein-1 (PD-1) signal...

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Bibliographic Details
Main Authors: Xuangjie Guo, Yiping Xu, Wei Luo, Rongli Fang, Li Cai, Ping Wang, Yuxia Zhang, Zhe Wen, Yanhui Xu
Format: Article
Language:English
Published: BMC 2021-07-01
Series:BMC Pediatrics
Subjects:
Biliary atresia
PD-1
IFN-γ
Online Access:https://doi.org/10.1186/s12887-021-02794-x

Internet

https://doi.org/10.1186/s12887-021-02794-x

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