Evidence for GTKO/β4GalNT2KO Pigs as the Preferred Organ-source for Old World Nonhuman Primates as a Preclinical Model of Xenotransplantation

Evidence for GTKO/β4GalNT2KO Pigs as the Preferred Organ-source for Old World Nonhuman Primates as a Preclinical Model of Xenotransplantation

Background. Triple-knockout (TKO) pigs (in which expression of the 3 known pig carbohydrate xenoantigens has been deleted) are likely to be an optimal source of organs for transplantation into human recipients, many of whom do not have natural antibodies against TKO pig cells. However, old world mon...

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Bibliographic Details
Main Authors: Yehua Cui, MD, Takayuki Yamamoto, MD, PhD, Syed Sikandar Raza, BA, Mahmoud Morsi, MD, Huy Quoc Nguyen, BS, David Ayares, PhD, David K.C. Cooper, MD, PhD, Hidetaka Hara, MD, PhD
Format: Article
Language:English
Published: Wolters Kluwer 2020-08-01
Series:Transplantation Direct
Online Access:http://journals.lww.com/transplantationdirect/fulltext/10.1097/TXD.0000000000001038

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http://journals.lww.com/transplantationdirect/fulltext/10.1097/TXD.0000000000001038

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