Design and Synthesis of New Quinoxaline Derivatives as Potential Histone Deacetylase Inhibitors Targeting Hepatocellular Carcinoma: In Silico, In Vitro, and SAR Studies

Design and Synthesis of New Quinoxaline Derivatives as Potential Histone Deacetylase Inhibitors Targeting Hepatocellular Carcinoma: In Silico, In Vitro, and SAR Studies

Guided by the structural optimization principle and the promising anticancer effect of the quinoxaline nucleus, a new series of novel HDAC inhibitors were designed and synthesized. The synthesized compounds were designed to bear the reported pharmacophoric features of the HDAC inhibitors in addition...

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Bibliographic Details
Main Authors: Chao Ma, Mohammed S. Taghour, Amany Belal, Ahmed B. M. Mehany, Naglaa Mostafa, Ahmed Nabeeh, Ibrahim H. Eissa, Ahmed A. Al-Karmalawy
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Chemistry
Subjects:
quinoxaline
anti-proliferative
HDAC
apoptosis
molecular modeling
structure-activity relationship
Online Access:https://www.frontiersin.org/articles/10.3389/fchem.2021.725135/full

Internet

https://www.frontiersin.org/articles/10.3389/fchem.2021.725135/full

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