Aspulvinone O, a natural inhibitor of GOT1 suppresses pancreatic ductal adenocarcinoma cells growth by interfering glutamine metabolism

Aspulvinone O, a natural inhibitor of GOT1 suppresses pancreatic ductal adenocarcinoma cells growth by interfering glutamine metabolism

Abstract Background Distinctive from their normal counterparts, cancer cells exhibit unique metabolic dependencies on glutamine to fuel anabolic processes. Specifically, pancreatic ductal adenocarcinoma (PDAC) cells rely on an unconventional metabolic pathway catalyzed by aspartate transaminase 1 (G...

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Bibliographic Details
Main Authors: Weiguang Sun, Shanshan Luan, Changxing Qi, Qingyi Tong, Shan Yan, Hua Li, Yonghui Zhang
Format: Article
Language:English
Published: BMC 2019-08-01
Series:Cell Communication and Signaling
Subjects:
Aspulvinone O
Pancreatic ductal adenocarcinoma cells
GOT1 inhibitor
Glutamine metabolism
Online Access:http://link.springer.com/article/10.1186/s12964-019-0425-4

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http://link.springer.com/article/10.1186/s12964-019-0425-4

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