Evolution of substrate specificity in a retained enzyme driven by gene loss

Evolution of substrate specificity in a retained enzyme driven by gene loss

The connection between gene loss and the functional adaptation of retained proteins is still poorly understood. We apply phylogenomics and metabolic modeling to detect bacterial species that are evolving by gene loss, with the finding that Actinomycetaceae genomes from human cavities are undergoing...

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Bibliographic Details
Main Authors: Ana Lilia Juárez-Vázquez, Janaka N Edirisinghe, Ernesto A Verduzco-Castro, Karolina Michalska, Chenggang Wu, Lianet Noda-García, Gyorgy Babnigg, Michael Endres, Sofía Medina-Ruíz, Julián Santoyo-Flores, Mauricio Carrillo-Tripp, Hung Ton-That, Andrzej Joachimiak, Christopher S Henry, Francisco Barona-Gómez
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-03-01
Series:eLife
Subjects:
evolution by gene loss
genome decay
enzyme substrate specificity
Actinomyces
Histidine and tryprophan biosynthesis
phosphoribosyl isomerase A
Online Access:https://elifesciences.org/articles/22679

Internet

https://elifesciences.org/articles/22679

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