Brain proteome changes in female Brd1+/− mice unmask dendritic spine pathology and show enrichment for schizophrenia risk

Brain proteome changes in female Brd1+/− mice unmask dendritic spine pathology and show enrichment for schizophrenia risk

Genetic and molecular studies have implicated the Bromodomain containing 1 (BRD1) gene in the pathogenesis of schizophrenia and bipolar disorder. Accordingly, mice heterozygous for a targeted deletion of Brd1 (Brd1+/− mice) show behavioral phenotypes with broad translational relevance to psychiatric...

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Bibliographic Details
Main Authors: Veerle Paternoster, Maria Svanborg, Anders Valdemar Edhager, Anto P. Rajkumar, Esben Ahlburg Eickhardt, Jonatan Pallesen, Jakob Grove, Per Qvist, Tue Fryland, Gregers Wegener, Jens Randel Nyengaard, Ole Mors, Johan Palmfeldt, Anders Dupont Børglum, Jane Hvarregaard Christensen
Format: Article
Language:English
Published: Elsevier 2019-04-01
Series:Neurobiology of Disease
Subjects:
Dendritic spine
Cytoskeleton
Proteomics
TMT10plex
Bromodomain containing 1
Animal model
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996118307678

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http://www.sciencedirect.com/science/article/pii/S0969996118307678

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