Brain proteome changes in female Brd1+/− mice unmask dendritic spine pathology and show enrichment for schizophrenia risk
Genetic and molecular studies have implicated the Bromodomain containing 1 (BRD1) gene in the pathogenesis of schizophrenia and bipolar disorder. Accordingly, mice heterozygous for a targeted deletion of Brd1 (Brd1+/− mice) show behavioral phenotypes with broad translational relevance to psychiatric...
Main Authors: | Veerle Paternoster, Maria Svanborg, Anders Valdemar Edhager, Anto P. Rajkumar, Esben Ahlburg Eickhardt, Jonatan Pallesen, Jakob Grove, Per Qvist, Tue Fryland, Gregers Wegener, Jens Randel Nyengaard, Ole Mors, Johan Palmfeldt, Anders Dupont Børglum, Jane Hvarregaard Christensen |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2019-04-01
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Series: | Neurobiology of Disease |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S0969996118307678 |
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