Correlation of homologous recombination deficiency induced mutational signatures with sensitivity to PARP inhibitors and cytotoxic agents

Correlation of homologous recombination deficiency induced mutational signatures with sensitivity to PARP inhibitors and cytotoxic agents

Abstract Background Homologous recombination (HR) repair deficiency arising from defects in BRCA1 or BRCA2 is associated with characteristic patterns of somatic mutations. In this genetic study, we ask whether inactivating mutations in further genes of the HR pathway or the DNA damage checkpoint als...

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Bibliographic Details
Main Authors: Ádám Póti, Hella Gyergyák, Eszter Németh, Orsolya Rusz, Szilárd Tóth, Csenger Kovácsházi, Dan Chen, Bernadett Szikriszt, Sándor Spisák, Shunichi Takeda, Gergely Szakács, Zoltan Szallasi, Andrea L. Richardson, Dávid Szüts
Format: Article
Language:English
Published: BMC 2019-11-01
Series:Genome Biology
Subjects:
Mutation signature
BRCA1
BRCA2
RAD51C
PALB2
RAD52
Online Access:http://link.springer.com/article/10.1186/s13059-019-1867-0

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http://link.springer.com/article/10.1186/s13059-019-1867-0

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