cGMP Imaging in Brain Slices Reveals Brain Region-Specific Activity of NO-Sensitive Guanylyl Cyclases (NO-GCs) and NO-GC Stimulators

cGMP Imaging in Brain Slices Reveals Brain Region-Specific Activity of NO-Sensitive Guanylyl Cyclases (NO-GCs) and NO-GC Stimulators

Impaired NO-cGMP signaling has been linked to several neurological disorders. NO-sensitive guanylyl cyclase (NO-GC), of which two isoforms—NO-GC1 and NO-GC2—are known, represents a promising drug target to increase cGMP in the brain. Drug-like small molecules have been discovered...

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Bibliographic Details
Main Authors: Stefanie Peters, Michael Paolillo, Evanthia Mergia, Doris Koesling, Lea Kennel, Achim Schmidtko, Michael Russwurm, Robert Feil
Format: Article
Language:English
Published: MDPI AG 2018-08-01
Series:International Journal of Molecular Sciences
Subjects:
Cyclic GMP
nitric oxide
guanylyl cyclase
NO-GC stimulators
Purkinje cells
cerebellar granule cells
striatum
hippocampal neurons
FRET imaging
transgenic mice
Online Access:http://www.mdpi.com/1422-0067/19/8/2313

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http://www.mdpi.com/1422-0067/19/8/2313

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